This course provides training in current molecular genetic investigation. Introductory lectures cover recombinant DNA and molecular genetic methodology, stressing overall experimental strategies. A combination of classic and current papers accompany the lecture material (1-2 papers per lecture), supported by readings from recent texts (particularly Recombinant DNA: Genes and Genomes, Watson et al., 3rd ed.). The course covers both the fundamentals and the current research methods for analysis of gene structure and gene expression, including transcriptional and posttranscriptional control. Modern genomics is introduced via discussion of the Human Genome Project. Topics in gene mapping and identification, genetic heterogeneity and comparative genomics are covered using examples from current literature. Developmental genetics and strategies of developmental regulation will be presented, and comparison made between the temporal and spatial control of gene expression in vertebrates and invertebrates. Genetic engineering topics include gene targeting and transgenesis, with applications to understanding tissue specific control of gene expression and mechanisms underlying human disease. The basics of DNA recombination, repair, and transposition are covered in relationship to cancer, evolution, and mutagenesis. Prerequisites: In addition to a college-level introductory biology class, a more advanced class in either genetics or biochemistry is required. This course is a prerequisite for HG 542.
Schedule: MWF 9am-10am; F 10am-11pm discussion
Location: Due to construction in 2007, several classrooms will be used, mostly North Lecture Hall and 5915 Buhl - check with the ctools website or class handouts for location and changes as it will vary !
Course Director: Robins
Instructors: Burke, Camper, Chan , Meisler, Moran, Robins, Wilson
Syllabus:
HG 542 will emphasize the principles and methods of genetics and molecular genetics as they relate to human disease. The course covers the topics of chromosome structure/function and chromosomal disorders, Mendelian inheritance and monogenic traits, non-Mendelian inheritance, complex genetic disorders and cancer genetics. In each section, principles of genetics are presented by way of illustration with human genetic diseases. Papers from the current and classic literature will supplement lecture material. HG 541 or equivalent is a prerequisite for this course.
Schedule: MWF 9am-10am
Location: 5915 Buhl
Course Director: Glover
Instructors: Glover, Antonellis, Camper, Moran, Burmeister, Gruber, Sekiguchi
Syllabus:
An expanded syllabus is available on ctools (login required)
The concepts and analytic methods for studying variation in human populations are the subject matter of this course. The topics covered include the distribution of genetic variation, major forces of genetic stasis and change, quantitative traits, linkage analysis, association tests, and the role of the environment. We take a problem solving approach and present the basic models of population, quantitative, and statistical genetics at a mathematical level appropriate to students in the life sciences. Our focus is on current human genetics research. However, most of what we present is broadly useful and applies to natural populations of other species.
Instructors: Long, Douglas
Syllabus:
This one-time course is offered in fall 2008 to accompany the Next-Generation Sequencing Technologies seminar series (http://www.hg.med.umich.edu/seminar.php). On the Friday before each Monday's seminar we will discuss 1-2 publications by the speaker, to better understand the research background, identify key questions, and critically examine the impact of the work. The discussion will be moderated by the faculty instructor or a U-M faculty familiar with the speaker's work.
Course Director: Li
Instructors: Li, other faculty
Syllabus: An expanded syllabus will be available on ctools (login required)
Enrollment: To enroll email Janet Miller. Please include your name and UMID.
Advanced course in population genetics, focusing on mathematical models and statistical methods for data analysis. Topics include infinite and finite population phenomena, population structure, admixture, mutation models, coalescent methods, recombination, and linkage disequilibrium.
Instructors: Rosenberg, Zollner
Note: 804 was replaced with Pharm502
HG803 is a 2-credit course intended for students who wish to gain further exposure to selected research topics and methods in genetics. The course is organized into four units/topics, each of which is covered in a series of two to four weekly two-hour sessions, supervised by faculty members with expertise in genetics research. Recently published research manuscripts from the genetics field represent the discussion material for each of the weekly sessions, and the discussion places a heavy emphasis on student-led presentations, critical analysis and active participation from all students enrolled in the course. Class size is limited to 12 students.
Topics and Faculty Moderators:
New Therapies for Genetic Disease: Jeff Innis, M.D., Ph.D. and Catherine Keegan, M.D., Ph.D.
Positional Cloning of Disease Genes: Friedhelm Hildebrandt, M.D.
Mammalian Developmental Genetics: Sally Camper, Ph.D.
MicroRNAs and RNA interference: John Kim, Ph.D.
Schedule: W 3pm-5pm
Location: Buhl, Room 5920
Course Director: Kim
Instructors: Hildebrandt, Camper, Kim, Innis, Keegan
This is a student seminar on genetics topics.
Schedule: W 12pm-1pm
Location: 5915 Buhl
Directors: Kohrman (course director), Burke, Martin, Antonellis
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