David Ginsburg, M.D.
Investigator, Howard Hughes Medical Institute
James V Neel Distinguished University Professor Internal Medicine & Human Genetics
Research Professor, Life Sciences Institute
Warner-Lambert/Parke-Davis Professor of Medicine
David Ginsburg is interested in understanding the components of the blood-clotting system and how disturbances in their function lead to human bleeding and blood-clotting disorders.
See:
http://www.hhmi.org/research/investigators/ginsburg.html
http://lsi.umich.edu/facultyresearch/labs/ginsburg
Nichols WC, Seligsohn U, Zivelin A, Terry VH, Hertel CE, Wheatley MA, Moussalli MJ, Hauri HP, Ciavarella N, Kaufman RJ, Ginsburg D. Mutations in the ER-Golgi intermediate compartment protein ERGIC-53 cause combined deficiency of coagulation factors V and VIII. Cell 93(1):61-70, 1998.
Mohlke KL, Purkayastha AA, Westrick RJ, Smith PL, Petryniak B, Lowe J, Ginsburg D. Mvwf, a dominant modifier of von Willebrand factor, results from altered lineage-specific expression of a glycosyltransferase. Cell 96(1):111-120, 1999.
Levy GG, Nichols WC, Lian EC, Foroud T, McClintick JN, McGee BM, Yang AY, Siemieniak DR, Stark KR, Gruppo R, Sarode R, Shurin SB, Chandrasekaran V, Stabler SP, Sabio H, Bouhassira EE, Upshaw JD Jr, Ginsburg D*, Tsai HM. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature 413(6855):488-494, 2001. [* corresponding author]
Zhang B, Cunningham MA, Nichols WC, Bernat JA, Seligsohn U, Pipe SW, McVey JH, Schulte-Overberg U, de Bosch NB, Ruiz-Saez A, White GC, Tuddenham EG, Kaufman RJ, Ginsburg D. Bleeding due to disruption of a cargo-specific ER to Golgi transport complex. Nat Genet 34(2):220-225, 2003.
Sun H, Ringdahl U, Homeister JW, Fay WP, Cary Engleberg NC, Yang AY, Rozek LS, Wang X, Sjöbring U, Ginsburg D. Plasminogen is a critical host pathogenicity factor for group A streptococcal infection. Science 305(5688):1283-1286, 2004.
Motto DG, Chauhan AK, Zhu G, Homeister J, Lamb CB, Desch KC, Zhang W, Tsai HM, Wagner DD, Ginsburg D. Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice. J Clin Invest 115(10):2752-2761, 2005.
Bernat JA, Crawford GE, Ogurtsov AY, Collins FS, Ginsburg D*, Kondrashov AS. Distant conserved sequences flanking endothelial-specific promoters contain tissue specific DNase-hypersensitive sites and over-represented motifs. Hum Mol Genet 15(13):2098-2105, 2006. [* corresponding author]
Lemmerhirt HL, Shavit JA, Levy GG, Cole SM, Long JC, Ginsburg D. Enhanced VWF biosynthesis and elevated plasma VWF due to a natural variant in the murine Vwf gene. Blood 108(9):3061-3067, 2006.
Buchner DA, Su F, Yamaoka JS, Kamei M, Shavit JA, Barthel LK, McGee B, Amigo JD, Kim S, Hanosh AW, Jagadeeswaran P, Goldman D, Lawson ND, Raymond PA, Weinstein BM, Ginsburg D*, Lyons SE. pak2a mutations cause cerebral hemorrhage in redhead zebrafish. Proc Natl Acad Sci USA 104(35):13996-14001, 2007 [* corresponding author].
Zhang B, Spreafico M, Zheng C, Yang A, Platzer P, Callaghan MU, Avci Z, Ozbek N, Mahlangu J, Haw T, Kaufman RJ, Marchant K, Tuddenham E, Seligsohn U, Peyvandi F, Ginsburg D. Genotype-phenotype correlation in combined deficiency of factor V and factor VIII. Blood 111(12):5592-5600, 2008.