Eric R. Fearon, M.D., Ph.D

Eric R. Fearon, M.D., Ph.D

Emanuel N. Maisel Professor of Oncology,
Professor of Internal Medicine,
Professor of Pathology, and
Professor of Human Genetics
Chief, Division of Molecular Medicine & Genetics

1504 BSRB, Box 2200
109 Zina Pitcher Place
Ann Arbor
48109 -2200
Staff Support: 
Mary Greene
Research Interests: 

Molecular analysis of human cancer pathogenesis; β-catenin-dependent Wnt signaling; transgenic and knockout mouse models of colorectal cancer; miRNAs and cancer; CDX2 homeobox gene function; factors and mechanisms regulating tissue stem cells and cell fate determination in intestinal epithelium.

The research in the Fearon laboratory seeks to address the means by which specific oncogene and tumor suppressor gene defects contribute to the pathogenesis of colon and other cancers and to develop novel strategies for early detection and treatment of colorectal adenomas and carcinomas.

Honors and Awards: 
2013 - Institute of Medicine of the National Academies
2012 - Shapiro Lecture, Perelman School of Medicine at the University of Pennsylvania
2007 - Johns Hopkins Univ Soc of Fellows
2005 - DSR Sarma Lecturer in Oncologic Pathology, Univ Toronto
2003 - Association of American Physicians
2000 - Lynch Lecturer, University of Notre Dame, Dept of Biology
1998 - American Society for Clinical Investigation (Vice-Pres, 2003-4; Pres-Elect, 2004-5; Pres, 2005-6)
1992-95 - McDonnell Fellow in Molecular Medicine in Cancer Research, James S. McDonnell Fund
1990 - Alpha Omega Alpha Honor Medical Society (JHU School of Medicine)
1990 - Wilson S. Stone Award, U. of Texas, M.D. Anderson Cancer Center
1983 - Phi Beta Kappa (Johns Hopkins Univ)
1990 The Johns Hopkins University, Ph.D. Biology/Program in Human Genetics
1990 The Johns Hopkins University School of Medicine, M.D.
1983 The Johns Hopkins University, B.A. Biophysics
Selected Publications: 

1. Bommer GT, Feng Y, Iura A, Giordano TJ, Kuick R, Kadikoy H, Sikorski D, Wu R, Cho KR, Fearon ER. IRS1 regulation by Wnt/β-catenin signaling and varied contribution of IRS1 to the neoplastic phenotype. J Biol Chem 2010, 285:1928-38. PMC2804351.

2. Miller SJ, Joshi BP, Feng, Y, Gaustad A, Fearon ER, Wang TD. In vivo fluorescence-based endocopic detection of colon dysplasia in the mouse using a novel peptide probe. PLoS One 2011, 6:e17384. PMC3050896.

3. Feng Y, Bommer GT, Zhao J, Green M, Sands E, Zhai Y, Brown K, Burberry A, Cho KR, Fearon ER. Mutant Kras promotes hyperplasia and altered differentiation in colon epithelium but does not expand the presumptive crypt stem cell pool. Gastroenterology 2011, 141:1003-13.e10. PMC3163826.

4. Feng Y, Sentani K, Wiese A, Sands E, Green M, Bommer GT, Cho KR, Fearon ER. Sox9 induction, ectopic Paneth cells, and mitotic spindle axis defects in mouse colon adenomatous epithelium arising from conditional biallelic Apc inactivation. Am J Pathol 2013, 183:493-503. PMC3730784

5. Zeller J, Turbiak AJ, Powelson IA, Lee S, Sun D, Showalter HD, Fearon ER. Investigation of 3-aryl-pyrimido(5,4-e]triazine-5,7-diones as small molecule antagonists of beta-catenin/TCF transcription. Bioorg Med Chem Lett 2013, Sep 7. pii: S0960-894X(13)01060-3. doi: 10.1016/j.bmcl.2013.08.111.