Jeff Kidd, Ph.D.
Assistant Professor of Human Genetics
Assistant Professor of Computational Medicine and Biology
We apply a genome-wide approach to understanding the processes that shape the structure, content, and sequence variation of genomes among human populations and between species. We seek to understand how biological and historic population processes act to shape genomic variation and how this variation leads to the wide range of phenotypic diversity observed in the natural world.
We take a genomics approach that involves high-throughput sequencing and genotyping with population-genetic modeling. We apply genomics approaches to address questions related to the biology of genomes in a range of systems including humans, non-human primates, and domestic dogs.
Henn BM, Gignoux CR, Jobin M, Granka JM, Macpherson JM, Kidd JM,
Rodríguez-Botigué L, Ramachandran S, Hon L, Brisbin A, Lin AA, Underhill PA,
Comas D, Kidd KK, Norman PJ, Parham P, Bustamante CD, Mountain JL, Feldman MW. (2011) Hunter-gatherer genomic diversity suggests a southern African origin for modern humans. Proc Natl Acad Sci U S A.
Kidd JM, Graves T, Newman TL, Fulton R, Hayden HS, Malig M, Kallicki J, Kaul R, Wilson RK, Eichler EE (2010) A human genome structural variation sequencing resource reveals insights into mutational mechanism. Cell. 143(5):837-47.
The 1000 Genomes Project Consortium (2010) A map of human genome variation from population scale sequencing. Nature. Oct 28;467(7319):1061-73.
Antonacci F, Kidd JM, Marques-Bonet T, Teague B, Ventura M, Girirajan S, Alkan C, Campbell CD, Vives L, Malig M, Rosenfeld JA, Ballif BC, Shaffer LG, Graves TA, Wilson RK, Schwartz DC, Eichler EE. (2010) A large and complex structural polymorphism at 16p12.1 underlies microdeletion disease risk. Nat. Genetics Sep;42(9):745-50.
Kidd JM, Sampas N, Antonacci F, Graves T, Fulton R, Hayden HS, Alkan C, Malig M, Ventura M, Giannuzzi G, Kallicki J, Anderson P, Tsalenko A, Yamada NA, Tsang P, Kaul R, Wilson RK, Bruhn L, Eichler EE. (2010) Characterization of missing human genome sequences and copy-number polymorphic insertions. Nat Methods. May;7(5):365-71.
Alkan C, Kidd JM, Marques-Bonet T, Aksay G, Antonacci F, Hormozdiari F, Kitzman JO, Baker C, Malig M, Mutlu O, Sahinalp SC, Gibbs RA, Eichler EE. (2009) Personalized copy number and segmental duplication maps using next-generation sequencing. Nat Genet. Oct;41(10):1061-7.
Marques-Bonet T, Kidd JM, Ventura M, Graves TA, Cheng Z, Hillier LW, Jiang Z, Baker C, Malfavon-Borja R, Fulton LA, Alkan C, Aksay G, Girirajan S, Siswara P, Chen L, Cardone MF, Navarro A, Mardis ER, Wilson RK, Eichler EE. (2009) A burst of segmental duplications in the genome of the African great ape ancestor. Nature. Feb 12;457(7231):877-81.
Kidd JM, Cheng Z, Graves T, Fulton B, Wilson RK, Eichler EE. (2008) Haplotype sorting using human fosmid clone end-sequence pairs. Genome Res. Dec;18(12):2016-23.
Kidd JM, Cooper GM, Donahue WF, Hayden HS, Sampas N, Graves T, Hansen N, Teague B, Alkan C, Antonacci F, Haugen E, Zerr T, Yamada NA, Tsang P, Newman TL, Tüzün E, Cheng Z, Ebling HM, Tusneem N, David R, Gillett W, Phelps KA, Weaver M, Saranga D, Brand A, Tao W, Gustafson E, McKernan K, Chen L, Malig M, Smith JD, Korn JM, McCarroll SA, Altshuler DA, Peiffer DA, Dorschner M, Stamatoyannopoulos J, Schwartz D, Nickerson DA, Mullikin JC, Wilson RK, Bruhn L, Olson MV, Kaul R, Smith DR, Eichler EE. (2008) Mapping and sequencing of structural variation from eight