Jun Li, Ph.D.

Assistant Professor of Human Genetics
Research Assistant Professor, Center for Computational Medicine and Biology
Faculty, Center for Statistical Genetics
Faculty Member, Comprehensive Cancer Center

5789 Med Sci II
1241 E. Catherine St. SPC 5618
Ann Arbor
MI
48109-5618
Phone: 
734-615-5754
Email: 
junzli@umich.edu
Lab Website: 
http://www.hg.med.umich.edu/labs/lilab/
Faculty Spotlight: 
http://hg.med.umich.edu/feature_li.php
Research Interests: 

The Li lab studies the genetic basis of complex human diseases using genomic approaches. Currently our interests include analyses of gene expression patterns in postmortem brain tissues associated with major depression, bipolar disorder, and schizophrenia, sequencing-based variant discovery and analysis in rare Mendelian disorders and the bipolar disorder, integrated analysis of cancer genome alterations, microbial dynamics in CF airways, and spontaneous mutations in the human genome.

Honors and Awards: 
2009-2011 NARSAD Young Investigator Award
2011-2014 Ellison Medical Foundation New Scholar in Aging
2011-2014 IMHRO – Johnson & Johnson Rising Star Translational Research Award
Education: 
1985- 1989 B.Sc., Department of Physics, Beijing University. Thesis: Computation of the Characteristic Inversion Rates of Semiconductor Lasers
1991- 1998 Ph.D., Division of Biology, California Institute of Technology. Thesis: Structure-function relationship and single-channel behavior of cyclic nucleotide-gated channels
1998- 2001 Postdoctoral fellow, Department of Genetics, Stanford University School of Medicine.
2001- 2007 Senior Scientist and project leader, Stanford Human Genome Center, Stanford University
Selected Publications: 

(Since 2007)

The Psychiatric GWAS Consortium (including J. Li). (2011) Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nature Genetics, 43: 977–983.

The Cancer Genome Atlas Research Network (including J. Li). (2011) Integrated Genomic Analyses of Ovarian Carcinoma. Nature, 474:609-15.

T. Pemberton, C. Wang, J. Z. Li, N. A. Rosenberg. (2010) Inference of unexpected genetic relatedness among individuals in HapMap Phase III. American Journal of Human Genetics. 87(4): 457-464.

N. Zhang, Y. Senbabaoglu, and J. Z. Li, (2010). Joint Estimation of DNA Copy Number from Multiple Platforms. Bioinformatics, 26(2):153-60.

N. Zhang, D. Siegmund, H. Ji, and J. Z. Li, (2009). Detecting simultaneous change points in multiple sequences. Biometrika, 97(3):631-645

L. J. Scott, P. Muglia, X. Kong, W. Guan, M. Flickinger, R.i Upmanyu, F. Tozzi, J. Li, M. Burmeister, D. Absher, R. C. Thompson, C. Francks, F. Meng, A. Antoniades, A. M. Southwick, A. Schatzberg, W. Bunney, J. Barchas, E. Jones, R. Day, K. Matthews, P. McGuffin, J. S. Strauss, J. L. Kennedy, L. Middleton, A. Roses, S. J. Watson, J. B. Vincent, R. M. Myers, A. E. Farmer, H. Akil, D. K. Burns, M. Boehnke. (2009). Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci U S A. 106(18):7501-7506

J. K. Pickrell, G. Coop, J. Novembre, S.r Kudaravalli, J. Li, D. Absher, B.S. Srinivasan, G. S. Barsh, R. M. Myers, M. W. Feldman, J. K. Pritchard. (2009). Signals of recent positive selection in a worldwide sample of human populations. Genome Res. 19(5):826-37

K. A. McGowan, J. Z. Li, C. Y. Park, V. Beaudry, H. K. Tabor, A. J. Sabnis1, W. Zhang, H. Fuchs, M. H. de Angelis, R. M. Myers, L. D. Attardi G. S. Barsh. (2008) Genetics of dark skin: ribosomal protein mutations act through p53. Nat Genet. 40(8):963-70.

The Cancer Genome Atlas Research Network (including J. Li). (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 255:1061-8.

J. Z. Li*, D. M. Absher*, H. Tang, A. M. Southwick, A. M. Casto, S. Ramachandran, H. M. Cann, G. S. Barsh, M. Feldman, L. L. Cavalli-Sforza, R. M. Myers. (2008). Worldwide human relationships inferred from genome-wide patterns of variation. Science, 319:1100-1104.

J. Z. Li, F. Meng, L. Tsavaler, S. J. Evans, P. V. Choudary, H. Tomita, M. P. Vawter, D. Walsh, V. Shokoohi, T. Chung, W. E. Bunney Jr., E. G. Jones, H. Akil, S. J. Watson, R. M. Myers (2007). Sample matching by inferred agonal stress in gene expression analyses of the brain. BMC Genomics, 8:336