Sundeep Kalantry, Ph.D.
Assistant Professor of Human Genetics
Our research aims to define the epigenetic mechanisms that regulate X-chromosome inactivation, which results in transcriptional silencing of most genes along one of the two X-chromosomes in female mammals.
Please see the lab website for a detailed description of our research program.
Gayen S, Maclary E, Hinten M, and Kalantry S. Sex-specific Silencing of X-linked Genes by Xist RNA. Proceedings of the National Academy of Sciences of the United States of America, 2016.
Hinten M, Maclary E, Gayen S, Harris C, and Kalantry S. Visualizing Long Non-coding RNAs on Chromatin. Methods in Molecular Biology, 1402:147-164, 2016.
Taniguchi K, Townshend RF, Freddo AM, Prakash A, Gayen S, Harris CE, Tsai Y-H, DeLong CJ, Chue DJ, Lopez SA, Spence JR, O’Shea KS, Margolis B, Kalantry S, and Gumucio DL. Pluripotent Stem Cells: An Improved Model of Lumen Formation. Stem Cell Reports 5:954-962, 2015.
Kalantry S and Mueller. Mary Lyon: A Tribute. Americal Journal of Human Genetics. October 1 97(4):507-511, 2015.
Ku C-J, Lim K-C, Kalantry S, Maillard I, Engel JD, Tomonori H: A mon- to biallelic T cell transcriptional switch regulates GATA3 abundance. Genes & Development. Sep 15;29(18):1930-41, 2015.
Sarkar MK, Gayen S, Kumar S, Maclary E, Buttigieg E, Hinten M, Kumari A, Harris C, Sado T, Kalantry S. An Xist Activating Antisense RNA Required for X-chromosome Inactivation. Nature Communications, October 19;6:8564, 2015.
Kang, J, Lienhard M, Pastor WA, Chawla A, Novotny M, Tsagaratou A, Lasken RS, Thompson EC, Surani MA, Koralov SB, Kalantry S, Chavez L, and Rao A. Simultaneous deletion of Tet1 and Tet3 increases transcriptional variability in early embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2015. PubMed PMID: 26199412.
Gayen S, Maclary E, Buttigieg E, Hinten M, Kalantry S. A Primary Role for the Tsix lncRNA in Maintaining Random X-Chromosome Inactivation. Cell Reports. 2015 May 26;11(8):1251-65.
Maclary E, Buttigieg E, Hinten M, Gayen S, Harris C, Sarkar MK, Purushothaman S, and Kalantry S. Differentiation-dependent requirement of Tsix long non-coding RNA in imprinted X-chromosome inactivation. Nature Communications, 5:4209, 2014.
Cao Q, Wang X, Zhao M, Yang R, Malik R, Qiao Y, Poliakov A, Yocum AK, Li Y, Chen W, Cao X, Jiang X, Dahiya A, Harris C, Feng FY, Kalantry S, Qin ZS, Dhanasekaran SM, and Chinnaiyan AM. The central role of EED in the orchestration of Polycomb Group complexes. Nature Communications, 5: 3127, 2014.
Maclary E, Hinten M, Harris C, and Kalantry, S. Long noncoding RNAs in the X-inactivation center. Chromosome Research, 21(6-7): 601-614, 2013.
Kang J, Kalantry S, and Rao A. PGC7, H3K9me2 and Tet3: regulators of DNA methylation in zygotes. Cell Research, 23(1): 6-9, 2013.
Jiao B, Ma H, Shokhirev MN, Drung A, Yang Q, Shin JD, Lu S, Byron M, Kalantry S, Mercurio A, Lawrence JB, Hoffmann A, Bach I. Paternal RLIM/Rnf12 is a survival factor for milk producing alveolar cells. Cell, 149 (3): 630-641, 2012.
Williams LH, Kalantry S, Starmer J, Magnuson T. Transcription precedes loss of Xist coating and depletion of H3K27me3 during X-chromosome reprogramming in the mouse inner cell mass. Development, 226 (7): 1714-1718, 2011.
Kalantry S. Recent advances in X-chromosome inactivation. Journal of Cellular Physiology, Feb 22, 2011. doi: 10.1002/jcp.22673. [Epub ahead of print]
Kalantry S, Purushothaman S, Bowen RB, Starmer J, and Magnuson T. Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation. Nature,460 :647-651, 2009.
Alexander MK, Mlynarczyk-Evans S, Royce-Tolland M, Plocik A, Kalantry S, Magnuson T, Panning B. Differences between homologous alleles of olfactory receptor genes require the Polycomb Group protein Eed. J Cell Biol, 179(2):269-276, 2007.
Kalantry S, Magnuson T. Epigenetic influences on gene expression pathways. In Principles of Developmental Genetics, S. A. Moody, ed. (Elsevier Academic Press) 2007.
Ciavatta D, Kalantry S, Magnuson T, Smithies O. A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation. PNAS, 103(26):9958-9963, 2006.
Kalantry S, Mills KC, Yee D, Otte A, Panning B, and Magnuson T. The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. Nature Cell Biology, 8(2):195-202, 2006.
Mlynarczyk-Evans S, Andersen, A A, Kalantry S, Gribnau J, Panning B. X Chromosomes Alternate between Two States prior to Random X-Inactivation. PLoS Biology, 4(6):e159, 2006.
Montgomery N, Chen, A, Kalantry S, Yee D, Chamberlain S, Otte A, Magnuson, T. The Polycomb PRC2 complex mediates mono-, di-, and tri-methylation of Histone H3-Lysine 27. Current Biology, 15(10):942-947, 2005.
Kalantry S, Manning S, Haub O, Tomihara-Newberger C, Lee H-G, Fangman J, Disteche CM, Manova K, and Lacy E. Amnionless, an essential gene for mouse gastrulation, encodes a visceral endoderm-specific protein with an extracellular cysteine-rich doman. Nature Genetics, 27:412-416, 2001.
Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman LP, Pandolfi PP. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nature Genetics 23(3):287-95, 1999.
Manova K, Tomihara-Newberger C, Wang S, Godelman A, Kalantry S, Witty-Blease K, De Leon V, Chen WS, Lacy E, and Bachvarova RF. Apoptosis in mouse embryos: elevated levels in pregastrulae and in the distal anterior region of gastrulae of normal and mutant mice. Developmental Dynamics., 213:293-308, 1998.
Kalantry S, Delva L, Gaboli M, Gandini D, Giorgio M, Hawe N, He LZ, Peruzzi D, Rivi R, Tribioli C, Wang ZG, Zhag H, Pandolfi PP. Gene rearrangements in the molecular pathogenesis of acute promyelocytic leukemia. J. Cell Physiol., 173(2):288-296, 1997.
Manova K, De Leon V, Angeles M, Kalantry S, Giarre M, Attisano L, Wrana J, Bachvarova RF. MRNAs for activin receports II and IIB are expressed in mouse oocytes and in the epiblast of pregastrula and gastrula stage mouse embryos. Mech Dev., 49(1-2):3-11, 1995.