Sundeep Kalantry, Ph.D.

Assistant Professor of Human Genetics

3710-D Med Sci II SPC 5618

1241 E. Catherine St.

Ann Arbor

48109-5618

Phone:

734-615-9578

Fax:

734-763-3784

Email:

kalantry@umich.edu

Lab Website:

http://www-personal.umich.edu/~kalantry/Kalantry_Lab/Welcome.html

Faculty Spotlight:

http://hg.med.umich.edu/spotlight/kalantry.html

Research Interests:

Our research aims to define the epigenetic mechanisms that regulate X-chromosome inactivation, which results in transcriptional silencing of most genes along one of the two X-chromosomes in female mammals.

Please see the lab website for a detailed description of our research program.

Honors and Awards:

2012-2014 March of Dimes Basil O'Connor Starter Scholar Research Award

2011-2016 NIH Director's New Innovator Award

2011-2015 Ellison Medical Foundation New Scholar in Aging

2009 Biological Sciences Scholar, University of Michigan

2007-12 NIH Pathway to Independence Award (K99/R00)

2003-06 American Cancer Society Postdoctoral Fellowship

2001 Julian R. Rachele Prize, Weill Graduate School of Medical Sciences of Cornell University

Education:

2002-2009 Postdoctoral Fellowship, University of North Carolina, Chapel Hill

1995-2001 Ph.D., Cell Biology and Genetics/Molecular Biology, Weill Graduate School of Medical Sciences of Cornell University, New York, NY

1989-93 B.A., Biochemistry, Cornell University, Ithaca, NY

Selected Publications:

Jiao B, Ma H, Shokhirev MN, Drung A, Yang Q, Shin JD, Lu S, Byron M, Kalantry S, Mercurio A, Lawrence JB, Hoffmann A, Bach I. Paternal RLIM/Rnf12 is a survival factor for milk producing alveolar cells. Cell, 149 (3): 630-641.

Williams LH, Kalantry S, Starmer J, Magnuson T. Transcription precedes loss of Xist coating and depletion of H3K27me3 during X-chromosome reprogramming in the mouse inner cell mass. Development, 226 (7): 1714-1718.

Kalantry S. Recent advances in X-chromosome inactivation. Journal of Cellular Physiology, Feb 22, 2011. doi: 10.1002/jcp.22673. [Epub ahead of print]

Kalantry S, Purushothaman S, Bowen RB, Starmer J, and Magnuson T. Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation. Nature,460 [7255]:647-651, 2009.

Alexander MK, Mlynarczyk-Evans S, Royce-Tolland M, Plocik A, Kalantry S, Magnuson T, Panning B. Differences between homologous alleles of olfactory receptor genes require the Polycomb Group protein Eed. J Cell Biol, 179(2):269-276, 2007.

Kalantry S, Magnuson T. Epigenetic influences on gene expression pathways. In Principles of Developmental Genetics, S. A. Moody, ed. (Elsevier Academic Press) 2007.

Ciavatta D, Kalantry S, Magnuson T, Smithies O. A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation. PNAS, 103(26):9958-9963, 2006.

Kalantry S, Mills KC, Yee D, Otte A, Panning B, and Magnuson T. The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. Nature Cell Biology, 8(2):195-202, 2006.

Mlynarczyk-Evans S, Andersen, A A, Kalantry S, Gribnau J, Panning B. X Chromosomes Alternate between Two States prior to Random X-Inactivation. PLoS Biology, 4(6):e159, 2006.

Montgomery N, Chen, A, Kalantry S, Yee D, Chamberlain S, Otte A, Magnuson, T. The Polycomb PRC2 complex mediates mono-, di-, and tri-methylation of Histone H3-Lysine 27. Current Biology, 15(10):942-947, 2005.

Kalantry S, Manning S, Haub O, Tomihara-Newberger C, Lee H-G, Fangman J, Disteche CM, Manova K, and Lacy E. Amnionless, an essential gene for mouse gastrulation, encodes a visceral endoderm-specific protein with an extracellular cysteine-rich doman. Nature Genetics, 27:412-416, 2001.

Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman LP, Pandolfi PP. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nature Genetics 23(3):287-95, 1999.

Manova K, Tomihara-Newberger C, Wang S, Godelman A, Kalantry S, Witty-Blease K, De Leon V, Chen WS, Lacy E, and Bachvarova RF. Apoptosis in mouse embryos: elevated levels in pregastrulae and in the distal anterior region of gastrulae of normal and mutant mice. Developmental Dynamics., 213:293-308, 1998.

Kalantry S, Delva L, Gaboli M, Gandini D, Giorgio M, Hawe N, He LZ, Peruzzi D, Rivi R, Tribioli C, Wang ZG, Zhag H, Pandolfi PP. Gene rearrangements in the molecular pathogenesis of acute promyelocytic leukemia. J. Cell Physiol., 173(2):288-296, 1997.

Manova K, De Leon V, Angeles M, Kalantry S, Giarre M, Attisano L, Wrana J, Bachvarova RF. MRNAs for activin receports II and IIB are expressed in mouse oocytes and in the epiblast of pregastrula and gastrula stage mouse embryos. Mech Dev., 49(1-2):3-11, 1995.