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Assistant Professor of Human Genetics Research Assistant Professor, Center for Computational Medicine and Biology |
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| 5789 Med Sci II 1241 E. Catherine St. SPC 5618 Ann Arbor, MI 48109 -5618 |
Phone: 734-615-5754 Email: junzli@umich.edu |
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The Li lab studies the genetic basis of complex human diseases. Currently our interests include analyses of gene expression patterns in postmortem brain tissues associated with major depression, bipolar disorder, and schizophrenia, genomewide association study of bipolar disorder, integrated data analysis for the Cancer Genome Atlas Project, population genetics studies, copy number variation in population and disease samples, and application of massively parallel sequencing methods to the projects mentioned above.
1985- 1989 B.Sc., Department of Physics, Beijing University. Thesis: Computation of the Characteristic Inversion Rates of Semiconductor Lasers
1991- 1998 Ph.D., Division of Biology, California Institute of Technology. Thesis: Structure-function relationship and single-channel behavior of cyclic nucleotide-gated channels
1998- 2001 Postdoctoral fellow, Department of Genetics, Stanford University School of Medicine.
2001- 2007 Senior Scientist and project leader, Stanford Human Genome Center, Stanford University
J. Bradley, J. Li, N. Davidson, H.A. Lester, K. Zinn. (1994). Heteromeric olfactory cyclic nucleotide-gated channels: A subunit that confers increased sensitivity to cAMP. Proc. Natl. Acad. Sci. 91:8890-8894. PMID: 7522325
J. Li, W.N. Zagotta, H.A. Lester. (1997). Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation. Quarterly Reviews of Biophysics. 30(2):177-193. PMID: 9293605
J. Li, H.A. Lester. (1999). Single-channel kinetics of the rat olfactory cyclic nucleotide-gated channels expressed in Xenopus oocytes. Mol Pharmacol. 55(5):883-93. PMID: 10220567
J. Li, H.A. Lester. (1999). A site-directed mutagenesis study of the ligand-binding domain of the cyclic nucleotide-gated channels. Mol Pharmacol. 55(5):873-82. PMID: 10220566
Li, J., Tabor, H., Gleason, C., Nguyen, L., Lotspeich, L., Spiker, D., Risch, N. and Myers, R. M. (2002). Lack of association between HoxA1 and HoxB1 gene variants and autism in 110 multiplex families. Amer. J. Med. Genet.: Neuropsychiatric Genet. 114: 24-30. PMID: 11840501
J. Noonan, J. Li, L. Nguyen, M. Dickson, C. Caoile, J. Grimwood, J. Schmutz, M.W. Feldman and R.M. Myers. 2003 Extensive linkage disequilibrium, a common 16.7 kb deletion and evidence of balancing selection in the human protocadherin a cluster. Am. J. Human. Genet. 72(3): 621-635. PMID: 12577201
W. E. Bunney, B. G. Bunney, M.P. Vawter, H. Tomita, J. Li, S. J. Evans, P. V. Choudary, R. M. Myers, E. G. Jones, S. J. Watson, H. Akil. 2003. Microarray technology: a review of new strategies to discover candidate vulnerability genes in psychiatric disorders. Am. J. Psychiatry. 160: 657-666. PMID: 12668351
S.J. Evans, P.V. Choudary, M.P. Vawter, J. Li, J.H. Meador-Woodruff, J.F. Lopez, S.M. Burke, R.C. Thompson, R.M. Myers, E.G. Jones, W.E. Bunney, S.J. Watson, H. Akil. 2003. DNA Microarray Analysis of Functionally Discrete Human Brain Regions Reveals Divergent Transcriptional Profiles. Neurobiol. Dis. 14(2):240-50. PMID: 14572446
M.P. Vawter, S.J. Evans, P.V. Choudary, H. Tomita, J.H. Meador-Woodruff, M. Molnar, J. Li, J.F. Lopez, R.M. Myers, D. Cox, S.J. Watson, H. Akil, E.G. Jones, W.E. Bunney. 2004. Gender Specific Gene Expression in Post-Mortem Human Brains: Localization to Sex Chromosomes. Neuropsychopharmacology. 29(2):373-84. PMID: 14583743
J. Li, L. Nguyen, C. Gleason, L. Lotspeich, D. Spiker, N. Risch, R.M. Myers. 2004 Lack of Evidence for an Association Between WNT2 and Reelin Polymorphisms and Autism. Am. J. Med. Genet. 126B: 51-57. PMID:15048648
J. Li, M.P. Vawter, D. Walsh, H. Tomita, S.J. Evans, P.V. Choudary, J.F. Lopez, A. Avelar, V. Shokoohi, T. Chung, O. Mesarwi, E.G. Jones, S.J. Watson, H. Akil, W.E. Bunney, R.M. Myers. 2004. Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions. Hum. Mol. Genet. 13 (6): 609-616. PMID: 14734628
H. Tomita, M.P. Vawter, D. Walsh, S.J. Evans, P.V. Choudary, J. Li, K.M. Overman, M.E. Atz, R.M. Myers, E.G. Jones, S.J. Watson, H. Akil, W.E. Bunney Jr. 2004. Effect of agonal and postmortem factors on gene expression profile: quality control in microarray analyses of postmortem human brain. Biol Psychiatry. 55(4):346-352. PMID: 14960286
S. Evans, P. Choudary, C. Neal, J. Li, M. Vawter, H. Tomita, J. Lopez, R. Thompson, F. Meng, J. Stead, D. Walsh, R. Meyers, W. Bunney, S Watson, E Jones, H Akil. 2004. Dysregulation of the Fibroblast Growth Factor (FGF) system in Major Depression. PNAS, 101: 15506-15511. PMID:15483108
J. Li, M Burmeister. 2005 Genetical Genomics: Combining Genetics with Gene Expression Analysis. Human Molecular Genetics, 14(suppl_2): R163-R169. PMID: 16244315
P.V. Choudary, M. Molnar, S.J. Evans, H. Tomita, J.Z. Li, M.P. Vawter, R.M. Myers, W.E. Bunney Jr., H. Akil, S.J. Watson & E.G. Jones. 2005 Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. PNAS. 102(43):15653-15658. PMID:16230605
A. M. Karssen*, J. Z. Li*, S. Her, P. D. Patel, F. Meng, S. J. Evans, M. P. Vawter, H. Tomita, P. V. Choudary, W. E. Bunney, Jr, E. G. Jones, S. J. Watson, H. Akil, R. M. Myers, A. F. Schatzberg, and D. M. Lyons. 2006 Application of microarray technology in primate behavioral neuroscience research. Methods, 38: 227–234. PMID: 16469505
M.P. Vawter, H. Tomita, F. Meng, B. Bolstad, J. Li, S. Evans, P. Choudary, M. Atz, L. Shao, C. Neal, D. Walsh, M. Burmeister, T. Speed, R. Myers, E.G. Jones, S.J. Watson, H. Akil, & W.E. Bunney. Mitochondrial Related Gene Expression Changes Are Sensitive to Agonal-pH State: Implications For Brain Disorders. Mol. Psych. 11(7): 663-679. PMID: 16636682
M. Atz, D. Walsh, P. Cartagena, J. Li, S. Evans, P. Choudary, K. Overman, R. Stein, H. Tomita, S. Potkin, R. Myers, S.J. Watson, E.G. Jones, H. Akil, W.E. Jr Bunney, M.P. Vawter. 2007 Methodological considerations for gene expression profiling of human brain. J Neurosci Methods. 163(2): 295-309. PMID: 17512057
A.N. Strehlow, J.Z. Li, R.M. Myers. 2007 Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space. Human Molecular Genetics. 16(4):391-409. PMID: 17189290
A. M. Karssen, S. Her, J. Z. Li, P. D. Patel, F. Meng, W. E. Bunney, Jr, E. G. Jones, S. J. Watson, H. Akil, R. M. Myers, A. F. Schatzberg, and D. M. Lyons. 2007 Stress-induced changes in primate prefrontal profiles of gene expression. Molecular Psychaitry. Epub Sep 25, 2007. PMID:16469505
J.W. Knowles, T.L. Assimes, J. Li , T. Quertermous, J.P. Cooke. 2007. Genetic Susceptibility to Peripheral Arterial Disease: A Dark Corner in Vascular Biology. Arteriosclerosis, Thrombosis, and Vascular Biology, 27(10): 2068-78
(Book Chapter) J. Li. 2007 Genetic association studies: concepts and applications, in "Current Topics in Human Genetics: Studies of Complex Diseases", World Scientific Publishing Co., Edited by. H. W. Deng, H. Shen, Y. J. Liu & H. Hu
J. Z. Li, F. Meng, L. Tsavaler, S. J. Evans, P. V. Choudary, H. Tomita, M. P. Vawter, D. Walsh, V. Shokoohi, T. Chung, W. E. Bunney Jr., E. G. Jones, H. Akil, S. J. Watson, R. M. Myers 2007. Sample matching by inferred agonal stress in gene expression analyses of the brain. BMC Genomics, 8:336. PMID: 17892578
J. Z. Li*, D. M. Absher*, H. Tang, A. M. Southwick, A. M. Casto, S. Ramachandran, H. M. Cann, G. S. Barsh, M. Feldman, L. L. Cavalli-Sforza, R. M. Myers 2008. Worldwide human relationships inferred from genome-wide patterns of variation. Science, 319:1100-1104. PMID: 18292342
J. W. Knowles, T. L. Assimes, E. Boerwinkle, S. P. Fortmann, A. Go, M. L. Grove, M. Hlatky, C. Iribarren, J. Li, R. Myers, N. Risch, S. Sidney, A. Southwick, K. A. Volcik and T. Quertermous. 2008 Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD. BMC Medical Genetics, 9(1):23. PMID: 18384690
T. L. Assimes, J. W. Knowles, A. Basu, C. Iribarren, A. Southwick, H. Tang, D. Absher, J. Li, J.M. Fair, G.D. Rubin, S. Sidney, S.P. Fortmann, A.S. Go, M.A. Hlatky, R.M. Myers, N. Risch, T. Quertermous. 2008 Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE Study. Hum Mol Genet. 17(15):2320-8. PMID: 18443000
K. A. McGowan, J. Z. Li, C. Y. Park, V. Beaudry, H. K. Tabor, A. J. Sabnis1, W. Zhang, H. Fuchs, M. H. de Angelis, R. M. Myers, L. D. Attardi G. S. Barsh. 2008 Genetics of dark skin: ribosomal protein mutations act through p53. Nature Genetics 40(8):963-70. PMID: 18641651
The Cancer Genome Atlas Research Network (including J. Li), Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 255:1061-8, 2008
L. J. Scott, P. Muglia, X. Kong, W. Guan, M. Flickinger, R.i Upmanyu, F. Tozzi, J. Li, M. Burmeister, D. Absher, R. C. Thompson, C. Francks, F. Meng, A. Antoniades, A. M. Southwick, A. Schatzberg, W. Bunney, J. Barchas, E. Jones, R. Day, K. Matthews, P. McGuffin, J. S. Strauss, J. L. Kennedy, L. Middleton, A. Roses, S. J. Watson, J. B. Vincent, R. M. Myers, A. E. Farmer, H. Akil, D. K. Burns, M. Boehnke. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry. Proc Natl Acad Sci USA. 106(18):7501-7506.
A. Itsara, G. M. Cooper, C. Baker, S. Girirajan, J. Li, D. Absher, R. Krauss, R. M. Myers, H. Mefford, H. S. Cann, A. A. Singleton, D. A. Nickerson, E. E. Eichler, Rare and Large Normal Copy Number Variation and Hotspots of Human Genetic Disease. Am J Hum Genet. 84:148-161.
J. K. Pickrell, G. Coop, J. Novembre, S.r Kudaravalli, J. Li, D. Absher, B.S. Srinivasan, G. S. Barsh, R. M. Myers, M. W. Feldman, J. K. Pritchard. Signals of recent positive selection in a worldwide sample of human populations. Genome Res. 19(5):826-837.
G. Coop, J. K. Pickrell, S. Kudaravalli, J. Novembre, J. Li, D. Absher, R. M. Myers, L. L. Cavalli-Sforza, M. W. Feldman, J. K. Pritchard. The role of geography in human adaptation. PLoS Genetics. 5(6):e1000500.
N.Zhang, D. Siegmund, H. Ji, and J. Z. Li, (2009). Detecting simultaneous change points in multiple sequences. Biometrika, In press.
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