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Professor of Human Genetics Professor of the Epidemiology Department Professor of Internal Medicine |
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| 1524 BSRB 109 Zina Pitcher Place Ann Arbor, MI 48109 -2200 |
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Research in the Gruber lab is focused on identifying genetic and environmental factors that contribute to the development of cancer. The goal of our research is to find new ways to prevent cancer and to improve treatment and care for cancer patients. Dr. Gruber also serves as the co-director of Biomedical Prevention for the University of Michigan Comprehensive Cancer Center with Dr. Dean Brenner.
H. Marvin Pollard Professor of Internal Medicine
American Society of Clinical Investigation - Elected Member
BS 1984 University of Pennsylvania
MPH 1986 Yale University
PhD 1988 Yale University (Epidemiology)
MD 1992 University of Pennsylvania
Residency, Internal Medicine 1992-1994 Hospital of the University of Pennsylvania
Fellowship, Medical Oncology 1994-1997 Johns Hopkins
Gruber SB, Moreno V, Rozek LS, Rennert HS, Lejbkowicz F, Bonner JD, Greenson JK, Giordano TJ, Fearon ER, Rennert G. Genetic Variation in 8q24 Associated with Risk of Colorectal Cancer. Cancer Biol Ther. 2007 Jul 2;6(7)
Gruber SB. Population stratification in epidemiologic studies of founder populations.
Cancer Biomark. 2007;3(3):123-8.
Kangelaris KN, Gruber SB. Clinical implications of founder and recurrent CDH1 mutations in hereditary diffuse gastric cancer. JAMA. 2007 Jun 6;297(21):2410-1.
Chen S, Wang W, Lee S, Nafa K, Lee J, Romans K, Watson P, Gruber SB, Euhus D, Kinzler KW, Jass J, Gallinger S, Lindor NM, Casey G, Ellis N, Giardiello FM, Offit K, Parmigiani G; Colon Cancer Family Registry. Prediction of germline mutations and cancer risk in the Lynch syndrome. JAMA. 2006 Sep 27;296(12):1479-87.
Hearle N, Schumacher V, Menko FH, Olschwang S, Boardman LA, Gille JJ, Keller JJ, Westerman AM, Scott RJ, Lim W, Trimbath JD, Giardiello FM, Gruber SB, Offerhaus GJ, de Rooij FW, Wilson JH, Hansmann A, Moslein G, Royer-Pokora B, Vogel T, Phillips RK, Spigelman AD, Houlston RS. Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res. 2006 May 15;12(10):3209-15.
Rozek LS, Lipkin SM, Fearon ER, Hanash S, Giordano TJ, Kuick R, Misek DE,Taylor JMG, Greenson JK, Rennert G, Gruber SB. CDX2 polymorphisms, RNA expression, and risk of colorectal cancer. Cancer Research, 65:5488-92,2005.
Begg CB, Orlow I, Hummer A, Armstrong BK, Kricker A, Marrett LD, MillikanRC, Gruber SB, Anton-Culver H, Zanetti R, Gallagher RP, Dwyer T, Rebbeck TR, Mitra N, Busam K, From L, Berwick M. Lifetime Risk of Melanoma in CDKN2A Mutation Carriers in a Population-Based Sample. Journal of the National Cancer Institute, 97 1507-1515, 2005.
Douglas JA, Gruber SB, Meister KA, Bonner JD, Watson P, Krush AJ, Lynch HT. History and Molecular Genetics of Hereditary Non-Polyposis Colorectal Cancer in Family G * A Century Later. JAMA, 294(17):2195-202, 2005
Poynter JN, Gruber SB, Higgins PD, Almog R, Bonner JD, Rennert HS, Low M, Greenson JK, Rennert G.Statins and the risk of colorectal cancer.New England Journal of Medicine, 2005. 352(21):2238-9.PDF
Lipkin SM, Rozek LS, Rennert G, Yang W, Chen PC, Hacia J, Hunt N, Shin B,Fodor S, Kokoris M, Greenson JK, Fearon E, Lynch H, Collins F, Gruber SB.The MLH1 D132H variant is associated with susceptibility to sporadic colorectalcancer.Nature Genetics, 2004. 36(7):694-9.PDF
Amend KL, Elder JT, Tomsho LP, Bonner JD, Johnson TM, Schwartz J, Berwick M,
Gruber SB.EGF gene polymorphism and the risk of incident primary melanoma.
Cancer Research, 2004. 64(8):2668-72.PDF
Niell BL, Rennert G, Bonner JD, Almog R, Tomsho LP, Gruber SB.BRCA1 and BRCA2 founder mutations and the risk of colorectal cancer.Journal of the National Cancer Institute, 2004. 96(1):15-21.PDF
Niell BL, Long JC, Rennert G, Gruber SB.Genetic anthropology of the colorectal cancer-susceptibility allele APC I1307K:evidence of genetic drift within the Ashkenazim.American Journal of Human Genetics, 2003. 73(6):1250-60. Epub 2003 Nov 17.PDF
Shedden KA, Taylor JM, Giordano TJ, Kuick R, Misek DE, Rennert G, Schwartz DR, Gruber SB, Logsdon C, Simeone D, Kardia SL, Greenson JK, Cho KR, Beer DG,Fearon ER, Hanash S.Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework. American Journal of Patholology, 2003. 163(5):1985-95.PDF
Foulkes WD, Thiffault I, Gruber SB, Horwitz M, Hamel N, Lee C, Shia J,Markowitz A, Figer A, Friedman E, Farber D, Greenwood CM, Bonner JD, Nafa K,Walsh T, Marcus V, Tomsho L, Gebert J, Macrae FA, Gaff CL, Paillerets BB,Gregersen PK, Weitzel JN, Gordon PH, MacNamara E, King MC, Hampel H, De LaChapelle A, Boyd J, Offit K, Rennert G, Chong G, Ellis NA.The founder mutation MSH2*1906G-->C is an important cause of hereditary nonpolyposis colorectal cancer in the Ashkenazi Jewish population. American Journal of Human Genetics, 2002. 71(6):1395-412. Epub 2002 Nov 26. PDF
Gruber SB, Ellis NA, Scott KK, Almog R, Kolachana P, Bonner JD, Kirchhoff T, Tomsho LP, Nafa K, Pierce H, Low M, Satagopan J, Rennert H, Huang H, Greenson JK, Groden J, Rapaport B, Shia J, Johnson S, Gregersen PK, Harris CC, Boyd J, Rennert G, Offit K. BLM heterozygosity and the risk of colorectal cancer. Science, 2002. 20;297(5589):2013. 2002 Oct 298(5594):751. PDF
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