Sundeep Kalantry , Ph.D.

Lab Webpage	Assistant Professor of Human Genetics
	3710-C Med Sci II 1241 E. Catherine St. Ann Arbor, MI 48109 -5618	Phone: 734-615-9578 Fax: 734-763-3784 Email: kalantry@umich.edu

Research Interests

Our research aims to define the epigenetic mechanisms that regulate X-chromosome inactivation, which results in transcriptional silencing of most genes along one of the two X-chromosomes in female mammals.

Please see the lab website for additional details

Honors and Awards

2009

Biological Sciences Scholar, University of Michigan

2007-12

NIH Pathway to Independence Award (K99/R00)

2003-06

American Cancer Society Postdoctoral Fellowship

2001

Julian R. Rachele Prize, Weill Graduate School of Medical Sciences of Cornell University

Education

2002-09

Postdoctoral Fellowship, University of North Carolina, Chapel Hill

1995-01

Ph.D., Cell Biology and Genetics/Molecular Biology, Weill Graduate School of Medical Sciences of
Cornell University, New York, NY

1989-93

B.A., Biochemistry, Cornell University, Ithaca, NY

Selected Publications

Kalantry S, Purushothaman S, Bowen RB, Starmer J, and Magnuson T. Evidence of Xist RNA-independent initiation of mouse imprinted X-chromosome inactivation., Nature,460 [7255]:647-651, 2009.

Alexander MK, Mlynarczyk-Evans S, Royce-Tolland M, Plocik A, Kalantry S, Magnuson T, Panning B. Differences between homologous alleles of olfactory receptor genes require the Polycomb Group protein Eed. J Cell Biol, 179(2):269-276, 2007.

Kalantry S, Magnuson T. Epigenetic influences on gene expression pathways. In Principles of Developmental Genetics, S. A. Moody, ed. (Elsevier Academic Press) 2007.

Ciavatta D, Kalantry S, Magnuson T, Smithies O. A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation. PNAS, 103(26):9958-9963, 2006.

Kalantry S, Mills KC, Yee D, Otte A, Panning B, and Magnuson T. The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. Nature Cell Biology, 8(2):195-202, 2006.

Mlynarczyk-Evans S, Andersen, A A, Kalantry S, Gribnau J, Panning B. X Chromosomes Alternate between Two States prior to Random X-Inactivation. PLoS Biology, 4(6):e159, 2006.

Montgomery N, Chen, A, Kalantry S, Yee D, Chamberlain S, Otte A, Magnuson, T. The Polycomb PRC2 complex mediates mono-, di-, and tri-methylation of Histone H3-Lysine 27. Current Biology, 15(10):942-947, 2005.

Kalantry S, Manning S, Haub O, Tomihara-Newberger C, Lee H-G, Fangman J, Disteche CM, Manova K, and Lacy E. Amnionless, an essential gene for mouse gastrulation, encodes a visceral endoderm-specific protein with an extracellular cysteine-rich doman. Nature Genetics, 27:412-416, 2001.

Zhong S, Delva L, Rachez C, Cenciarelli C, Gandini D, Zhang H, Kalantry S, Freedman LP, Pandolfi PP. A RA-dependent, tumour-growth suppressive transcription complex is the target of the PML-RARalpha and T18 oncoproteins. Nature Genetics 23(3):287-95, 1999.

Manova K, Tomihara-Newberger C, Wang S, Godelman A, Kalantry S, Witty-Blease K, De Leon V, Chen WS, Lacy E, and Bachvarova RF. Apoptosis in mouse embryos: elevated levels in pregastrulae and in the distal anterior region of gastrulae of normal and mutant mice. Developmental Dynamics., 213:293-308, 1998.

Kalantry S, Delva L, Gaboli M, Gandini D, Giorgio M, Hawe N, He LZ, Peruzzi D, Rivi R, Tribioli C, Wang ZG, Zhag H, Pandolfi PP. Gene rearrangements in the molecular pathogenesis of acute promyelocytic leukemia. J. Cell Physiol., 173(2):288-296, 1997.

Manova K, De Leon V, Angeles M, Kalantry S, Giarre M, Attisano L, Wrana J, Bachvarova RF. MRNAs for activin receports II and IIB are expressed in mouse oocytes and in the epiblast of pregastrula and gastrula stage mouse embryos. Mech Dev., 49(1-2):3-11, 1995.