 |
Associate Professor of Human Genetics Associate Research Professor, Bioinformatics Associate Research Professor, Life Sciences Institute |
|
| 2017 Palmer Commons 100 Washtenaw Ave. Ann Arbor, MI 48109 -2218 |
Phone: 734-615-5510 Email: rnoah@umich.edu |
|
We study problems in evolutionary biology and human genetics through a combination of mathematical modeling, computer simulations, development of statistical methods, and inference from population-genetic data.
(1) Human genetic variation, and inferring human genetic history from genome-wide microsatellite, insertion/deletion, and single-nucleotide polymorphisms. We are also interested in how distributions of complex genetic diseases across populations have arisen from human evolutionary history, and in using genetic variation to inform the development of statistical approaches for identifying disease genes.
(2) Gene trees and species trees, and incorporating the different signals produced by different parts of a genome into tools for phylogenetic reconstruction. More generally, we are studying the properties of gene genealogies in cases where lineages from several populations or species are considered.
(3) Theoretical population genetics. Recent topics of interest include the effect of gene duplication on microsatellite polymorphisms, the measurement of linkage disequilibrium using homozygosity, and the computation of the lengths of adaptive walks through spaces of DNA sequences.
2001 Stanford University, Ph.D.
1999 Stanford University, M.S.
1997 Rice University, B.A.
NA Rosenberg, MGB Blum. Sampling properties of homozygosity-based statistics for linkage disequilibrium. Mathematical Biosciences 208: 33-47 (2007).
DF Conrad, M Jakobsson, G Coop, X Wen, JD Wall, NA Rosenberg, JK Pritchard. A worldwide survey of haplotype variation and linkage disequilibrium in the human genome. Nature Genetics 38: 1251-1260 (2006).
NA Rosenberg, M Nordborg. A general population-genetic model for the production by population structure of spurious genotype-phenotype associations in discrete, admixed or spatially distributed populations. Genetics 173: 1665-1678 (2006).
JH Degnan, NA Rosenberg. Discordance of species trees with their most likely gene trees. PLoS Genetics 2: 762-768 (2006).
S Ramachandran, O Deshpande, CC Roseman, NA Rosenberg, MW Feldman, LL Cavalli-Sforza. Support from the relationship of genetic and geographic distance in human populations for a serial founder effect originating in Africa. Proceedings of the National Academy of Sciences USA 102: 15942-15947 (2005).
H Innan, K Zhang, P Marjoram, S Tavaré, NA Rosenberg. Statistical tests of the coalescent model based on the haplotype frequency distribution and the number of segregating sites. Genetics 169: 1763-1777 (2005).
NA Rosenberg. The shapes of neutral gene genealogies in two species: probabilities of monophyly, paraphyly, and polyphyly in a coalescent model. Evolution 57: 1465-1477 (2003).
NA Rosenberg, JK Pritchard, JL Weber, HM Cann, KK Kidd, LA Zhivotovsky, MW Feldman. Genetic structure of human populations. Science 298: 2381-2385 (2002).
Home