 |
Assistant Professor of Human Genetics Assistant Professor of Internal Medicine-MMG |
|
| 5814 Med Sci II 1241 E. Catherine St. SPC 5618 Ann Arbor, MI 48109 -5618 |
||
Structural Maintenance of Chromosomes (SMC) proteins are conserved from bacteria to humans for their essential roles in higher order chromosome organization. SMC proteins form multi-subunit protein complexes that affect virtually every aspect of chromosome-related processes including chromosome segregation, gene expression and DNA damage response and repair. Recently, mutations in SMC and SMC-related genes in humans have been linked to developmental disorders. Yet the vast majority of SMC studies have only examined SMC functions in a single cell and not in the context of development. The combination of C. elegans genetics and cell biology provides powerful tools to dissect the in vivo functions of SMC protein complexes at both the molecular and cellular levels and their overall influence on the complex multicellular organism. Research in my laboratory has recently discovered a novel developmentally regulated function for a specific SMC protein complex in the germ cell lineage. Our preliminary results indicate that this SMC complex plays an important role for maintaining genomic stability of germ cells and their progenitor cells. Ongoing efforts of my lab are focused on addressing the functional roles for SMC complexes in genomic stability, cell division and gametogenesis.
1993-1996 Cellular and Molecular Biology Training Grant, UCLA
1996 Molecular Biology Institute Graduate Fellowship, UCLA
1999-2002 Leukemia and Lymphoma Society Postdoctoral Fellowship
1991 B.A., Pomona College, Claremont, CA (Molecular Biology)
1997 Ph.D., University of California, Los Angeles, CA (Molecular Biology, Dr. Douglas L. Black)
Postdoctoral Training
1998-2006 University of California, Berkeley, CA (Dr. Barbara J. Meyer)
Rieseberg, L. H. , Choi, H., Chan, R., and Spore, C. (1993) Genomic map of a diploid hybrid species. Heredity 70, 285-293.
Min, H., Chan, R. C., and Black, D. L. 1995. The generally expressed hnRNP F is involved in a neural-specific pre-mRNA splicing event. Genes Dev. 9, 2659-2671.
Chan, R. C. and Black, D. L. 1995. Conserved intron elements repress splicing of a neuron-specific c-src exon in vitro. Mol. Cell. Biol. 15, 6377-6385.
Chan, R. C. and Black, D. L. 1997. The polypyrimidine tract binding protein binds upstream of neural cell-specific c-src exon N1 to repress the splicing of the intron downstream. Mol. Cell. Biol. 17, 4667-76.
Chu, D. S., Dawes, H. E., Lieb, J. D., Chan, R. C., Kuo, A. F., and Meyer, B. J. 2002. A molecular link between gene-specific and chromosome-wide transcriptional repression. Genes Dev. 16, 796-805.
Chan, R. C., Chan, A., Jeon, M., Wu, T. F., Pasqualone, D., Rougvie, A. E., and Meyer, B. J. 2003. Chromosome cohesion is regulated by a clock gene paralogue TIM-1. Nature 423, 1002-1009.
Chan, R. C., Severson, A. F., and Meyer, B. J. 2004. Condensin restructures chromosomes in preparation for meiotic divisions. J. Cell Biol. 167, 613-625.
Black, D. L., Chan, R. C., Min, H., Wang, J., and Bell, L. 1998. The Electrophoretic Mobility Shift Assay for RNA Binding Proteins. In RNA:Protein Interactions: A Practical Approach (ed. C. W. J. Smith), pp.109-136. Oxford University Press, Oxford.
Home